Compassionate Allowance List 2023 – Check CAL Conditions by SSA

Compassionate Allowances are a way to quickly identify diseases and other medical conditions that, by definition, meet Social Security’s standards for disability benefits. These conditions primarily include certain cancers, adult brain disorders and a number of rare disorders that affect children, check compassionate allowance list here. The CAL initiative helps us reduce waiting time to reach a disability determination for individuals with the most serious disabilities.

The Compassionate Allowances program identifies claims where the applicant’s disease or condition clearly meets Social Security’s statutory standard for disability. By incorporating cutting-edge technology, the agency can easily identify potential Compassionate Allowances to quickly make decisions. Social Security Administration (SSA) uses the same rules to evaluate CAL conditions when evaluating both Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI) programs.

SSA receives information from the public, comments received from the Social Security and Disability Determination Service communities, counsel from medical and scientific experts, research with the National Institutes of Health (NIH), and information received from past public outreach hearings regarding potential CAL conditions.

Compassionate Allowance List 2023

• Acute Leukemia
• Adrenal Cancer – with distant metastases or inoperable, unresectable or recurrent
• Adult Non-Hodgkin Lymphoma
• Adult Onset Huntington Disease
• Aicardi-Goutieres Syndrome
• Alexander Disease (ALX) – Neonatal and Infantile
• Allan-Herndon-Dudley Syndrome
• Alobar Holoprosencephaly
• Alpers Disease
• Alpha Mannosidosis – Type II and III
• ALS/Parkinsonism Dementia Complex
• Alstrom Syndrome
• Alveolar Soft Part Sarcoma
• Amegakaryocytic Thrombocytopenia
• Amyotrophic Lateral Sclerosis (ALS)
• Anaplastic Adrenal Cancer – Adult with distant metastases or inoperable, unresectable or recurrent
• Angelman Syndrome
• Angioimmunoblastic T-Cell Lymphoma (New)
• Angiosarcoma
• Aortic Atresia
• Aplastic Anemia
• Astrocytoma – Grade III and IV
• Ataxia Telangiectasia
• Atypical Teratoid/Rhabdoid Tumor
• Batten Disease
• Beta Thalassemia Major
• Bilateral Optic Atrophy- Infantile
• Bilateral Retinoblastoma
• Bladder Cancer – with distant metastases or inoperable or unresectable
• Blastic Plasmacytoid Dendritic Cell Neoplasm (New)
• Breast Cancer – with distant metastases or inoperable or unresectable
• Canavan Disease (CD)
• CACH–Vanishing White Matter Disease-Infantile and Childhood Onset Forms
• Carcinoma of Unknown Primary Site
• Cardiac Amyloidosis- AL Type
• Caudal Regression Syndrome – Types III and IV
• CDKL5 Deficiency Disorder
• Cerebro Oculo Facio Skeletal (COFS) Syndrome
• Cerebrotendinous Xanthomatosis
• Charlevoix-Saguenay Spastic Ataxia
• Child Lymphoblastic Lymphoma
• Child Lymphoma
• Child Neuroblastoma – with distant metastases or recurrent
• Chondrosarcoma – with multimodal therapy
• Choroid Plexus Carcinoma
• Chronic Idiopathic Intestinal Pseudo Obstruction
• Chronic Myelogenous Leukemia (CML) – Blast Phase
• CIC-rearranged Sarcoma
• Coffin-Lowry Syndrome
• Congenital Lymphedema
• Congenital Myotonic Dystrophy
• Congenital Zika Syndrome
• Cornelia de Lange Syndrome – Classic Form
• Corticobasal Degeneration
• Creutzfeldt-Jakob Disease (CJD) – Adult
• Cri du Chat Syndrome
• Degos Disease – Systemic
• DeSanctis Cacchione Syndrome
• Desmoplastic Mesothelioma
• Desmoplastic Small Round Cell Tumors
• Dravet Syndrome
• Duchenne Muscular Dystrophy- Adult
• Early-Onset Alzheimer’s Disease
• Edwards Syndrome (Trisomy 18)
• Eisenmenger Syndrome
• Endometrial Stromal Sarcoma
• Endomyocardial Fibrosis
• Ependymoblastoma (Child Brain Cancer)
• Erdheim Chester Disease
• Esophageal Cancer
• Esthesioneuroblastoma
• Ewing Sarcoma
• Farber Disease (FD) – Infantile
• Fatal Familial Insomnia
• Fibrodysplasia Ossificans Progressiva
• Fibrolamellar Cancer
• Follicular Dendritic Cell Sarcoma – metastatic or recurrent
• Friedreichs Ataxia (FRDA)
• Frontotemporal Dementia (FTD), Picks Disease -Type A – Adult
• Fryns Syndrome
• Fucosidosis – Type 1
• Fukuyama Congenital Muscular Dystrophy
• Fulminant Giant Cell Myocarditis
• Galactosialidosis – Early and Late Infantile Types
• Gallbladder Cancer
• Gaucher Disease (GD) – Type 2
• Gerstmann-Straussler-Scheinker Disease (New)
• Giant Axonal Neuropathy
• Glioblastoma Multiforme (Brain Cancer)
• Glioma Grade III and IV
• Glutaric Acidemia – Type II
• GM1 Gangliosidosis – Infantile and Juvenile Forms
• Head and Neck Cancers – with distant metastasis or inoperable or unresectable
• Heart Transplant Graft Failure
• Heart Transplant Wait List – 1A/1B
• Hemophagocytic Lymphohistiocytosis (HLH) – Familial Type
• Hepatoblastoma
• Hepatopulmonary Syndrome
• Hepatorenal Syndrome
• Histiocytosis Syndromes
• Hoyeraal-Hreidarsson Syndrome
• Hutchinson-Gilford Progeria Syndrome
• Hydranencephaly
• Hypocomplementemic Urticarial Vasculitis Syndrome
• Hypophosphatasia Perinatal (Lethal) and Infantile Onset Types
• Hypoplastic Left Heart Syndrome
• I Cell Disease
• Idiopathic Pulmonary Fibrosis
• Infantile Free Sialic Acid Storage Disease
• Infantile Neuroaxonal Dystrophy (INAD)
• Infantile Neuronal Ceroid Lipofuscinoses
• Inflammatory Breast Cancer (IBC)
• Intracranial Hemangiopericytoma
• Jervell and Lange-Nielsen Syndrome
• Joubert Syndrome
• Junctional Epidermolysis Bullosa – Lethal Type
• Juvenile Onset Huntington Disease
• Kidney Cancer – inoperable or unresectable
• Kleefstra Syndrome
• Krabbe Disease (KD) – Infantile
• Kufs Disease – Type A and B
• Large Intestine Cancer – with distant metastasis or inoperable, unresectable or recurrent
• Late Infantile Neuronal Ceroid Lipofuscinoses
• Leigh’s Disease
• Leiomyosarcoma
• Leptomeningeal Carcinomatosis
• Lesch-Nyhan Syndrome (LNS)
• Lewy Body Dementia
• Liposarcoma – metastatic or recurrent
• Lissencephaly
• Liver Cancer
• Lowe Syndrome
• Lymphomatoid Granulomatosis – Grade III
• Malignant Brain Stem Gliomas – Childhood
• Malignant Ectomesenchymoma
• Malignant Gastrointestinal Stromal Tumor
• Malignant Germ Cell Tumor
• Malignant Multiple Sclerosis
• Malignant Renal Rhabdoid Tumor
• Mantle Cell Lymphoma (MCL)
• Maple Syrup Urine Disease
• Marshall-Smith Syndrome
• Mastocytosis – Type IV
• MECP2 Duplication Syndrome
• Medulloblastoma – with metastases
• Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
• Megalencephaly Capillary Malformation Syndrome
• Menkes Disease – Classic or Infantile Onset Form
• Merkel Cell Carcinoma – with metastases
• Merosin Deficient Congenital Muscular Dystrophy
• Metachromatic Leukodystrophy (MLD) – Late Infantile
• Microvillus Inclusion Disease – Child (New)
• Mitral Valve Atresia
• Mixed Dementias
• Mowat-Wilson Syndrome (New)
• MPS I, formerly known as Hurler Syndrome
• MPS II, formerly known as Hunter Syndrome
• MPS III, formerly known as Sanfilippo Syndrome
• Mucosal Malignant Melanoma
• Multicentric Castleman Disease
• Multiple System Atrophy
• Myelodysplastic Syndrome with Excess Blasts (New)
• Myoclonic Epilepsy with Ragged Red Fibers Syndrome
• Neonatal Adrenoleukodystrophy
• Nephrogenic Systemic Fibrosis
• Neurodegeneration with Brain Iron Accumulation – Types 1 and 2
• NFU-1 Mitochondrial Disease
• Nicolaides-Baraister Syndrome
• Niemann-Pick Disease (NPD) – Type A
• Niemann-Pick Disease-Type C
• Nonketotic Hyperglycinemia
• Non-Small Cell Lung Cancer
• Nut Carcinoma (New)
• Obliterative Bronchiolitis
• Ohtahara Syndrome
• Oligodendroglioma Brain Cancer- Grade III
• Ornithine Transcarbamylase (OTC) Deficiency
• Orthochromatic Leukodystrophy with Pigmented Glia
• Osteogenesis Imperfecta (OI) – Type II
• Osteosarcoma, formerly known as Bone Cancer – with distant metastases or inoperable or unresectable
• Ovarian Cancer – with distant metastases or inoperable or unresectable
• Pallister-Killian Syndrome
• Pancreatic Cancer
• Paraneoplastic Pemphigus
• Patau Syndrome (Trisomy 13)
• Pearson Syndrome
• Pelizaeus-Merzbacher Disease-Classic Form
• Pelizaeus-Merzbacher Disease-Connatal Form
• Pericardial Mesothelioma
• Peripheral Nerve Cancer – metastatic or recurrent
• Peritoneal Mesothelioma
• Peritoneal Mucinous Carcinomatosis
• Perry Syndrome
• Pfeiffer Syndrome – Types II and III (New)
• Phelan-McDermid Syndrome
• Pitt Hopkins Syndrome
• Pleural Mesothelioma
• Pompe Disease – Infantile
• Pontocerebellar Hypoplasia (New)
• Posterior Cortical Atrophy (New)
• Primary Central Nervous System Lymphoma
• Primary Effusion Lymphoma
• Primary Peritoneal Cancer
• Primary Progressive Aphasia
• Progressive Bulbar Palsy
• Progressive Multifocal Leukoencephalopathy
• Progressive Supranuclear Palsy
• Prostate Cancer – Hormone Refractory Disease – or with visceral metastases
• Pulmonary Atresia
• Pulmonary Kaposi Sarcoma
• Refractory Hodgkin Lymphoma
• Renal Amyloidosis – AL Type (New)
• Renpenning Syndrome
• Retinopathy of Prematurity – Stage V
• Rett (RTT) Syndrome
• Revesz Syndrome
• Rhabdomyosarcoma
• Rhizomelic Chondrodysplasia Punctata
• Richter Syndrome
• Roberts Syndrome
• Rubinstein-Taybi Syndrome
• Salivary Cancers
• Sandhoff Disease
• Sarcomatoid Mesothelioma (New)
• Schindler Disease – Type 1
• SCN8A Related Epilepsy with Encephalopathy
• Seckel Syndrome
• Secondary Adenocarcinoma of the Brain
• Severe Combined Immunodeficiency – Childhood
• Single Ventricle
• Sinonasal Cancer
• Sjogren-Larsson Syndrome
• Skin Malignant Melanoma with Metastases
• Small Cell Cancer (Large Intestine, Prostate or Thymus)
• Small Cell Cancer of the Female Genital Tract
• Small Cell Lung Cancer
• Small Intestine Cancer – with distant metastases or inoperable, unresectable or recurrent
• Smith Lemli Opitz Syndrome
• Soft Tissue Sarcoma – with distant metastases or recurrent
• Spinal Muscular Atrophy (SMA) – Types 0 and 1
• Spinal Nerve Root Cancer-metastatic or recurrent
• Spinocerebellar Ataxia
• Stiff Person Syndrome
• Stomach Cancer – with distant metastases or inoperable, unresectable or recurrent
• Subacute Sclerosing Panencephalitis
• Superficial Siderosis of the Central Nervous System
• SYNGAP1-related NSID
• Tabes Dorsalis
• Tay Sachs Disease – Infantile Type
• Taybi-Linder Syndrome
• Tetrasomy 18p
• Thanatophoric Dysplasia – Type 1
• Thyroid Cancer
• Transplant Coronary Artery Vasculopathy
• Tricuspid Atresia
• Ullrich Congenital Muscular Dystrophy
• Ureter Cancer – with distant metastases or inoperable, unresectable or recurrent
• Usher Syndrome – Type I
• Ventricular Assist Device Recipient – Left, Right, or Biventricular
• Walker Warburg Syndrome
• Wolf-Hirschhorn Syndrome
• Wolman Disease
• X-Linked Lymphoproliferative Disease
• X-Linked Myotubular Myopathy
• Xeroderma Pigmentosum
• Zellweger Syndrome

Compassionate Allowances Conditions PDF must be checked before submitting your name for consideration.

Official Website for Compassionate Allowance

Visit the Compassionate Allowance website homepage to check CAL conditions and applying for the same.

You can use online services to apply for benefits, check the status of your claim or appeal, request a replacement Social Security card (in many areas), get an instant benefit verification letter, and much more.